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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Human Physiology</journal-id><journal-title-group><journal-title xml:lang="en">Human Physiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Физиология человека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0131-1646</issn><issn publication-format="electronic">3034-6150</issn><publisher><publisher-name xml:lang="en">The Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">685305</article-id><article-id pub-id-type="doi">10.31857/S0131164625010011</article-id><article-id pub-id-type="edn">VNZNXZ</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Visual contrast sensitivity in schizophrenia and schizotypic disorder</article-title><trans-title-group xml:lang="ru"><trans-title>Контрастная чувствительность при шизофрении и шизотипическом расстройстве</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shoshina</surname><given-names>I. I.</given-names></name><name xml:lang="ru"><surname>Шошина</surname><given-names>И. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kosikova</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Косикова</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedorova</surname><given-names>A. S.</given-names></name><name xml:lang="ru"><surname>Федорова</surname><given-names>А. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Smolyaninova</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Смольянинова</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Moritz</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Моритц</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Limankin</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Лиманкин</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Torgovtsev</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Торговцев</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Hanko</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Ханько</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lyapunov</surname><given-names>S. I.</given-names></name><name xml:lang="ru"><surname>Ляпунов</surname><given-names>С. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fernandez</surname><given-names>T. P.</given-names></name><name xml:lang="ru"><surname>Фернандес</surname><given-names>Т.</given-names></name></name-alternatives><address><country country="BR">Brazil</country></address><bio xml:lang="en"><p>Department of Psychology</p></bio><bio xml:lang="ru"><p>Департамент психологии</p></bio><email>shoshinaii@mail.ru</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Saint Petersburg State University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО Санкт-Петербургский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Kashchenko Psychiatric Hospital № 1</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургская городская психиатрическая больница № 1 имени П.П. Кащенко</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Prokhorov General Physics Institute, RAS</institution></aff><aff><institution xml:lang="ru">Институт общей физики имени А.М. Прохорова, РАН</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Federal University of Paraiba (UFPB)</institution></aff><aff><institution xml:lang="ru">Федеральный университет Параиба (UFPB)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2025</year></pub-date><volume>51</volume><issue>1</issue><fpage>3</fpage><lpage>12</lpage><history><date date-type="received" iso-8601-date="2025-06-19"><day>19</day><month>06</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Russian Academy of Sciences</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Российская академия наук</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Russian Academy of Sciences</copyright-holder><copyright-holder xml:lang="ru">Российская академия наук</copyright-holder></permissions><self-uri xlink:href="https://genescells.com/0131-1646/article/view/685305">https://genescells.com/0131-1646/article/view/685305</self-uri><abstract xml:lang="en"><p>Schizophrenia is characterized by a wide range of symptoms that also manifest themselves in other disorders, which served as the basis for the emergence of ideas about schizophrenia spectrum disorders. Studies indicate inconsistency of data on the characteristics of visual contrast sensitivity in schizophrenia and schizotypal disorder, which is part of the structure of schizophrenia spectrum disorders. The study involved 30 patients diagnosed with paranoid schizophrenia; 18 patients with schizotypal disorder and 30 people without psychopathology and neurological diseases. Contrast sensitivity was recorded when presenting Gabor elements with a spatial frequency from 0.4 to 10 cycles/deg, using the adaptive staircase procedure. Contrast sensitivity in both the schizophrenia group and the schizotypal disorder group was lower in the area of high spatial frequencies, compared to the conditionally healthy control. Thus, the identified disorders are common to both schizophrenia and schizotypal disorder. The obtained data are considered as evidence of a special nature of the discordance in the interaction of the magnocellular and parvocellular channels of the visual system with a shift towards the dominance of the magnocellular system.</p></abstract><trans-abstract xml:lang="ru"><p>Шизофрения характеризуется широким спектром симптомов, которые проявляются и при других расстройствах, что послужило основанием для появления представлений о расстройствах шизофренического спектра. Исследования указывают на противоречивость данных о характеристиках визуальной контрастной чувствительности при шизофрении и шизотипическом расстройстве, входящем в структуру расстройств шизофренического спектра. В исследовании приняли участие 30 пациентов с диагнозом параноидная шизофрения; 18 пациентов с шизотипическим расстройством и 30 чел. без психопатологии и неврологических заболеваний. Контрастную чувствительность регистрировали при предъявлении элементов Габора с пространственной частотой от 0.4 до 10 цикл/град, используя адаптивно-лестничную процедуру. Контрастная чувствительность как в группе больных шизофренией, так и пациентов с шизотипическим расстройством была ниже в области высоких пространственных частот, по сравнению с условно здоровым контролем. Таким образом, выявленные нарушения являются общими как для шизофрении, так и для шизотипического расстройства. Полученные данные рассматриваются как свидетельства своеобразного характера рассогласования взаимодействия магноцеллюлярных и парвоцеллюлярных каналов зрительной системы со сдвигом в сторону доминирования магноцеллюлярной системы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>contrast sensitivity</kwd><kwd>schizophrenia</kwd><kwd>schizotypal disorder</kwd><kwd>magnocellular system</kwd><kwd>parvocellular system</kwd><kwd>dorsal and ventral cortical pathway</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>контрастная чувствительность</kwd><kwd>шизофрения</kwd><kwd>шизотипическое расстройство</kwd><kwd>магноцеллюлярная система</kwd><kwd>парвоцеллюлярная система</kwd><kwd>дорсальный и вентральный корковый путь</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">Российский научный фонд</institution></institution-wrap><institution-wrap><institution xml:lang="en">Russian Science Foundation</institution></institution-wrap></funding-source><award-id>24-25-00494</award-id></award-group></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Siever L.J., Davis K.L. 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