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Exposure of developing organism to endocrine disruptingchemicals is an emerging scientific problem of wide concern

Genes & Cells: Vol XIV, №4, 2019, pp: 52-57 DOI: 10.23868/201906019

Authors

D.A. Tsomartova, N.V. Yaglova, S.V. Nazimova, S.S. Obernikhin, V.V. Yaglov

Dichlorodiphenyltrichloroethane (DDT) is considered to be one of the most wide-spread endocrine disruptors. Exposure of humans to low doses of DDT occurs around the globe. The present study was undertaken to elucidate the role of canonical Wnt-signaling in postnatal morphogenesis of the adrenal medulla in intact and developmentally exposed to DDT rats. The research was performed on male Wistar rats in pubertal (42nd day) and postpubertal (70thday) periods which were exposed to DDT during both prenatal and postnatal and only postnatal development. Adrenal histology showed enlargement of the adrenal medulla due to equal development of chromaffine cells and blood vessels from 42nd to 70th day in the intact rats and slower development of the adrenal medulla in the prenatally and postnatally exposed rats. Age-dependent changes in activation of canonical Wnt-signaling in the intact rats and altered Wnt-signaling along with impaired postnatal morphogenesis of the adrenal medulla in the DDT-exposed rats were found. The data obtained shows that prenatal exposure to DDT unlike postnatal exposure causes a more profound decrease in activation of canonical Wnt-signaling in adrenal chromaffine cells and impairs the development of adrenal medulla parenchyma.

Keywords: adrenal, chromaffine cells, β-catenin, canonical wnt-signaling, morphogenesis, endocrine disrupter, DDT.

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