Поиск Кабинет

Investigation of HLA-DRB1 and IL28 gene polymorphism in patients with varying severity of covid-19 infection

Genes & Cells: Vol XVI, №3, 2021, pp: 86-90

DOI: 10.23868/202110012

 

Авторы

S.N. Kolyubaeva, A.A. Kondratenko, K. Alkhazhe, E.V. Kryukov, V.A. Kachnov, R.I. Glushakov, T.S. Sveklina, L.A. Myakoshina, M.S. Tyuryupov, E.G. Neronova, M.I. Eliseeva

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Реферат

The work analyzed the polymorphisms of the HLA-DRB1 and IL28 genes in 100 patients who underwent COVID-19 with the development of infection with varying degrees of severity. To a mild degree of severity were patients without complications in the form of infectious pneumonate, to moderate and severe degrees — with the development of pneumonate with varying degrees of lung damage. In general, the distribution of alleles in patients with COVID-19 did not differ from the distribution of average values in Russia. However, the HLA-DRB1 *01 и *07 alleles were more common. Comparison of the frequency of HLA-DRB1 alleles in patients with COVID-19 with varying severity revealed more common alleles of *13 and *07 in the severety severe group. However, with OR of 3.2 and 1.8, their confidence intervals (CL) were in the range of 0.9–9.8 and 0.7–4.5 respectively. At severe severity, the presence of homozigotic variants of allele *07 is noted. (Fisher exact test, r.0.04). As for the IL28B gene, no statistically significant differences from the control group were found.

Keywords: patients, severity of the disease, infectious pneumonit, polymorphism of genes HLA-DRB1 and IL28B, alleles.

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