Localized gtex database and its potential applications in biomedical research

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Efficient analysis of large amounts of transcriptome data requires fast and easy access to raw gene expression data. In our work, we localized the available expression data of more than 50000 genes in 54 tissues from approximately 1000 individuals from the GTEx system and created an easy-to-use interface for accessing and selecting these data. Using the capabilities of the localized system, we selected seven genes with highly stable expression from the housekeeping genes, investigated the changes in the number and activity of mast cells in the tibial artery with aging, studied changes in the components of the intestinal barrier and the state of mucosal immunity in old age in connection with the increased incidence of ulcerative colitis after 60 years. These examples demonstrate the applicability of the localized GTEx database in various biomedical projects and applications.

Авторлар туралы

G. Churakov

Institute of Experimental Medicine; Saint Petersburg State Pediatric University

St. Petersburg, 197022 Russia; St. Petersburg, 194100 Russia

M. Belyakov

St. Petersburg State University

St. Petersburg, 199034 Russia

T. Sall

Institute of Experimental Medicine

St. Petersburg, 197022 Russia

S. Orlov

Institute of Experimental Medicine; St. Petersburg State University

Email: serge@iem.spb.ru
St. Petersburg, 197022 Russia; St. Petersburg, 199034 Russia

Әдебиет тізімі

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