Synthesis and antifungal activity of new sulfides with fragments of metronidazole and monoterpenoids

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The reaction of bromoacetylmetronidazole with monoterpene thiols of pinane and bornane structures yielded new sulfides, which were tested for antimicrobial activity and cytotoxicity. Compounds with fragments of myrtane and myrtentiols showed fungicidal activity against yeast fungi Candida albicans, Candida tropicalis and Candida parapsilosis, while derivatives with fragments of hydroxypinane thiols were not toxic to cells of the lung epithelium of the cow embryo.

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作者简介

S. Subbotina

Federal Research Center “Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences”

Email: lezina-om@yandex.ru
ORCID iD: 0009-0001-0512-3478

Institute of Chemistry

俄罗斯联邦, Syktyvkar, 167000

O. Lezina

Federal Research Center “Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences”

编辑信件的主要联系方式.
Email: lezina-om@yandex.ru
ORCID iD: 0000-0002-6105-5641

Institute of Chemistry

俄罗斯联邦, Syktyvkar, 167000

O. Grebyonkina

Federal Research Center “Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences”

Email: lezina-om@yandex.ru
ORCID iD: 0000-0002-1982-104X

Institute of Chemistry

俄罗斯联邦, Syktyvkar, 167000

D. Sudarikov

Federal Research Center “Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences”

Email: lezina-om@yandex.ru
ORCID iD: 0000-0001-5640-6956

Institute of Chemistry

俄罗斯联邦, Syktyvkar, 167000

S. Lisovskaya

Kazan Scientific Research Institute of Epidemiology and Microbiology; Kazan State Medical University

Email: lezina-om@yandex.ru
ORCID iD: 0000-0002-4377-2567
俄罗斯联邦, Kazan, 420015; Kazan, 420012

A. Kayumov

Kazan Federal University

Email: lezina-om@yandex.ru
ORCID iD: 0000-0001-7195-1557

Institute of Fundamental Medicine and Biology

俄罗斯联邦, Kazan, 420008

S. Rubtsova

Federal Research Center “Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences”

Email: lezina-om@yandex.ru
ORCID iD: 0000-0003-1224-8751

Institute of Chemistry

俄罗斯联邦, Syktyvkar, 167000

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