Колокализация нейротрансмиттеров в гиппокампе и афферентных системах: возможная функциональная роль

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В нейрофизиологии трансмиттерный фенотип считается признаком нейронной идентичности. С конца прошлого века стало известно, что нервная клетка может использовать для связи с другими нейронами несколько разных молекул. Это могут быть «классические» трансмиттеры: глутамат или гамма-аминомасляная кислота (либо ацетилхолин, серотонин, норадреналин), а также вторичные мессенджеры, в основном нейропептиды, выделяющиеся из тех же самых нейронов. Если классические нейромедиаторы совместно высвобождаются из одной и той же нервной клетки, говорят о котрансмиссии или корелизинге (выделении из одних и тех же везикул). В данной обзорной статье используется термин «котрансмиссия» в широком смысле, обозначая нейроны, которые высвобождают более одного классического медиатора. Поскольку трансмиттеры часто являются промежуточными продуктами метаболизма и обнаруживаются во многих клетках, классификация нейронов в настоящее время основана на белках-переносчиках (транспортерах), «упаковывающих» синтезируемые в цитоплазме нейромедиаторы в везикулы. Вопрос о колокализации основных нейротрансмиттеров у млекопитающих ограничивается здесь нейронами гиппокампа и тех структур, которые посылают к нему свои пути. В обзоре рассматриваются проблемы, затрагивающие механизмы мультитрансмиттерного сигналинга, а также вероятной функциональной роли колокализации медиаторов в работе гиппокампа. Предполагается, что коэкспрессия разных медиаторных фенотипов участвует в поддержании баланса возбуждения и торможения в разных регионах гиппокампа; способствует быстрому выбору способов обработки информации, индукции долговременной потенциации, поддержанию пространственного кодирования клетками места, а также обеспечению гибкости обучения и формированию рабочей памяти. Однако функциональная роль колокализации медиаторов, а также механизмов выделения «двойных» трансмиттеров окончательно не выяснены. Решение данных проблем продвинет некоторые направления фундаментальной нейронауки и поможет в терапии тех заболеваний, где обнаруживается нарушение баланса возбуждения и торможения, например эпилепсии, болезни Альцгеймера и многих других.

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В. Ф. Кичигина

ФГБУН Институт теоретической и экспериментальной биофизики РАН

Автор, ответственный за переписку.
Email: vkitchigina@gmail.com
Россия, 142290 Пущино, Московская обл.

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2. Рис. 1. Схема синаптической архитектуры «двойных» (VGLUT3+ и VGAT+) нейронов, выделяющих глутамат и ГАМК из отдельных синаптических пузырьков в независимых асимметричных или симметричных синапсах. Адаптировано из [79], с разрешения Elsevier (лицензия № 5922371097009 от 05 декабря 2024 г.). ГАМК – гамма-аминомасляная кислота; VGLUT3+-везикулы – положительные везикулярные транспортеры глутамата; VGAT+-везикулы – положительные везикулярные транспортеры ГАМК

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3. Рис. 2. Схематическое представление нейронов и аксонов в области CA1 гиппокампа и дорзальной зубчатой извилины, выявляющих колокализацию нейротрансмиттеров

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