ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency


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Abstract

Nature is the chief source of various remedies which are used to cure various diseases. Boswellic acid (BA) is a secondary metabolite from the pentacyclic terpenoid compound groups that are derived from the plant genus Boswellia. The oleo gum resins of these plants are primarily composed of polysaccharides, with the remaining amounts of resin (30-60%) and essential oils (5-10%) soluble in organic solvents. BA and its analogs are also reported to exhibit various in vivo and biological responses for example anti-inflammatory, anti-tumor, free radical scavenging activity, etc. Among all analogs, 11-keto-β-boswellic acid (KBA) and 3-O-acetyl-11-keto-β-boswellic acid (AKBA) has been demonstrated to be the most effective at reducing cytokine production and inhibiting the inflammatory responsecausing enzymes. In this review, we summarized the computational ADME prediction via the SwissADME computational tool and the structure-activity relationship of the Boswellic acid scaffold for the aspect of anticancer and antiinflammatory potency. In addition to these research findings which are associated with the therapy of acute inflammation and some cancers, the potential of boswellic acids against other disorders was also discussed.

About the authors

Akhalesh Kumar

Department of Pharmacy, Maharishi University of Information Technology

Email: info@benthamscience.net

Saurabh Sharma

Faculty of Pharmacy, Kalinga University

Email: info@benthamscience.net

Sudhanshu Mishra

Department of Pharmaceutical Science & Technology, Madan Mohan Malaviya University of Technology

Author for correspondence.
Email: info@benthamscience.net

Smriti Ojha

Department of Pharmaceutical Science & Technology, Madan Mohan Malaviya University of Technology

Email: info@benthamscience.net

Pawan Upadhyay

Department of Pharmacy, Maharishi University of Information Technology

Email: info@benthamscience.net

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