Precision Therapy for Prostate Cancer: Advancements in Polymeric Nanocarrier Systems

  • Authors: Kumar L.1, Rana R.2, Shaikh N.3, Kumar S.4, Aggarwal V.5, Komal K.6, Jyothiraditya V.7
  • Affiliations:
    1. Department of Pharmaceutics, GNA School of Pharmacy, GNA University
    2. Department of Pharmaceutical Sciences (Pharmaceutics), Himachal Institute of Pharmaceutical Education and Research (HIPER)
    3. Department of Quality Assurance, Smt. N. M. Padalia Pharmacy College
    4. Department of Pharmaceutical Chemistry, Himachal Institute of Pharmaceutical Education and Research (HIPER)
    5. , Senior Pharmacovigilance Specialist, Continuum India LLP
    6. Department of Pharmacology, Chandigarh College of Pharmacy
    7. Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences
  • Issue: Vol 25, No 14 (2025)
  • Pages: 978-992
  • Section: Chemistry
  • URL: https://genescells.com/1871-5206/article/view/694438
  • DOI: https://doi.org/10.2174/0118715206360906241223120425
  • ID: 694438

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Abstract

Introduction: Prostate cancer is a major worldwide health concern, and existing treatments often face challenges such as drug resistance, systemic toxicity, and insufficient targeting. Polymeric nanocarriers are currently employed as sophisticated tools in the field of oncology, offering the possibility to augment the administration and efficacy of anticancer therapies. In order to effectively eradicate prostate cancer, this review delves into the function of polymeric nanocarriers.

Methods: Databases such as PubMed, ScienceDirect, and Google Scholar were utilized to do a comprehensive literature assessment. For this search, we used terms like \"polymeric nanocarriers,\" \"prostate cancer,\" \"drug delivery,\" and \"nanotechnology.\"

Results: Studies have shown that polymeric nanocarriers greatly improve the delivery and effectiveness of treatments for prostate cancer. Nanocarriers enhance the solubility, stability, and bioavailability of drugs, resulting in improved therapeutic effects. Functionalization using targeting ligands, such as folic acid and prostate-specific membrane antigen (PSMA) antibodies, has demonstrated the ability to enhance targeted specificity, resulting in a decrease in off-target effects and systemic toxicity. Polymeric nanocarriers facilitate precise and prolonged drug delivery, leading to elevated drug levels in tumor tissues.

Conclusion: Polymeric nanocarriers are a notable breakthrough in the management of prostate cancer, providing precise medication administration, decreased toxicity, and improved therapy effectiveness. However, additional study is necessary to enhance the design of nanocarriers, evaluate their long-term safety, and enable their use in clinical applications. Continued interdisciplinary research and collaboration are essential for addressing current obstacles and maximizing the promise of polymeric nanocarriers in the treatment of prostate cancer.

About the authors

Lalit Kumar

Department of Pharmaceutics, GNA School of Pharmacy, GNA University

Author for correspondence.
Email: info@benthamscience.net

Ritesh Rana

Department of Pharmaceutical Sciences (Pharmaceutics), Himachal Institute of Pharmaceutical Education and Research (HIPER)

Email: info@benthamscience.net

Nusrat Shaikh

Department of Quality Assurance, Smt. N. M. Padalia Pharmacy College

Email: info@benthamscience.net

Sumit Kumar

Department of Pharmaceutical Chemistry, Himachal Institute of Pharmaceutical Education and Research (HIPER)

Email: info@benthamscience.net

Vikas Aggarwal

, Senior Pharmacovigilance Specialist, Continuum India LLP

Email: info@benthamscience.net

Komal Komal

Department of Pharmacology, Chandigarh College of Pharmacy

Email: info@benthamscience.net

Vuluchala Jyothiraditya

Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences

Email: info@benthamscience.net

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