Alterations of Krüppel-like Factor Signaling and Potential Targeted Therapy for Hepatocellular Carcinoma

  • Authors: Fang R.1, Sha C.2, Xie Q.3, Yao D.4, Yao M.2
  • Affiliations:
    1. Research Center of Clinical Medicine, Department of Medical Immunology,, Affiliated Hospital of Nantong University, Medical School of Nantong University,
    2. Research Center of Clinical Medicine, Department of Medical Immunology, Affiliated Hospital of Nantong University, Medical School of Nantong University
    3. Department of Infectious Diseases,, Nantong Haian People’s Hospital
    4. Research Center of Clinical Medicine, Department of Medical ImmunologyCenter of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University
  • Issue: Vol 25, No 2 (2025)
  • Pages: 75-85
  • Section: Oncology
  • URL: https://genescells.com/1871-5206/article/view/694474
  • DOI: https://doi.org/10.2174/0118715206301453240910044913
  • ID: 694474

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Full Text

Abstract

Krüppel-like factors (KLFs, total 18 members) from the zinc finger protein (ZFP) super-family have a wide range of biological functions in hepatocellular carcinoma (HCC). This paper reviews the recent some progresses of aberrant KLFs with their potential values for diagnosis, prognosis, and targeted therapy in HCC. The recent advances of oncogenic KLFs in the diagnosis, prognosis, and targeted therapy of HCC were reviewed based on the related literature on PUBMED and clinical investigation. Based on the recent literature, KLFs, according to biological functions in HCC, are divided into 4 subgroups: promoting (KLF5, 7, 8, 13), inhibiting (KLF3, 4, 9~12, 14, 17), dual (KLF2, 6), and unknown functions (KLF1, 15, 16, or 18 ?). HCC-related KLFs regulate downstream gene transcription during hepatocyte malignant transformation, participating in cell proliferation, apoptosis, invasion, and metastasis. Some KLFs have diagnostic or prognostic value, and other KLFs with inhibiting promoting function or over-expressing inhibiting roles might be molecular targets for HCC therapy. These data have suggested that Abnormal expressions of KLFs were associated with HCC progression. Among them, some KLFs have revealed the clinical values of diagnosis or prognosis, and other KLFs with the biological functions of promotion or inhibition might be as effectively molecular targets for HCC therapy.

About the authors

Rongfei Fang

Research Center of Clinical Medicine, Department of Medical Immunology,, Affiliated Hospital of Nantong University, Medical School of Nantong University,

Email: info@benthamscience.net

Chunxiu Sha

Research Center of Clinical Medicine, Department of Medical Immunology, Affiliated Hospital of Nantong University, Medical School of Nantong University

Email: info@benthamscience.net

Qun Xie

Department of Infectious Diseases,, Nantong Haian People’s Hospital

Email: info@benthamscience.net

Dengfu Yao

Research Center of Clinical Medicine, Department of Medical ImmunologyCenter of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University

Author for correspondence.
Email: info@benthamscience.net

Min Yao

Research Center of Clinical Medicine, Department of Medical Immunology, Affiliated Hospital of Nantong University, Medical School of Nantong University

Author for correspondence.
Email: info@benthamscience.net

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