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The Ubiquitin+Proteasome Protein Degradation Pathway as a Therapeutic Strategy in the Treatment of Solid Tumor Malignancies
J. Driscoll J., Minter A., A. Driscoll D., K. Burris J.
Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines
M. Cazal C., Choosang K., Gisele P. Severino V., S. Soares M., Lucio F. Sarria A., B. Fernandes J., Fatima G.F. Silva M., Cezar Vieira P., Pakkong P., M. Almeida G., Helena Vasconcelos M., S.J. Nascimento M., M.M. Pinto M.
Design, Synthesis, and Molecular Docking Studies of Indolo[3,2-c]Quinolines as Topoisomerase Inhibitors
Badr M., Elmongy E., Sayed I., Moemen Y., Khalil A., Elkhateeb D., Binsuwaidan R., Ali H.
An Antidepressant Drug Increased TRAIL Receptor-2 Expression and Sensitized Lung Cancer Cells to TRAIL-induced Apoptosis
Zinnah K., Newaz Munna A., Seol J., Park B., Park S.
Design, Synthesis, and Antiproliferative Activity of Quinazolin-4-One/Chalcone Hybrids via the EGFR Inhibition Pathway
Hisham M., Hassan H., Gomaa H., Youssif B., Hayalah A., Abdel-Aziz M.
Triptolide Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma via Akt/mTOR Pathway
Zheng Z., Yan G., Xi N., Xu X., Zeng Q., Wu Y., Zheng Y., Zhang G., Wang X.
JDHY3 Inhibits Hypopharyngeal Carcinoma Cell Proliferation and Promotes Apoptosis by Inhibiting the PI3K/AKT Pathway
Dai W., Ni Z., Zhang G., Xu J., Qin X., Cao J., Liu L.
Cytotoxicity and Apoptosis Induced by a Plumbagin Derivative in Estrogen Positive MCF-7 Breast Cancer Cells
Sagar S., Esau L., Moosa B., Khashab N., Bajic V., Kaur M.
Targeting Breast Cancer with N-Acetyl-D-Glucosamine: Integrating Machine Learning and Cellular Assays for Promising Results
Baysal Ö., Genç D., Silme R.S., Kırboğa K.K., Çoban D., Ghafoor N.A., Tekin L., Bulut O.
Osmundacetone Inhibits Angiogenesis of Infantile Hemangiomas through Inducing Caspases and Reducing VEGFR2/MMP9
Ke C., Chen C., Yang M., Chen H., Li L., Ke Y.
Antidepressant Sertraline Hydrochloride Inhibits the Growth of HER2+ AU565 Breast Cancer Cell Line through Induction of Apoptosis and Cell Cycle Arrest
Fayyaz S., Atia-Tul-Wahab , Irshad R., Siddiqui R., Choudhary M.
Phytol and α-Bisabolol Synergy Induces Autophagy and Apoptosis in A549 Cells and Additional Molecular Insights through Comprehensive Proteome Analysis via Nano LC-MS/MS
Kiruthiga C., Niharika K., Devi K.
Trans-platinum(II)/(IV) Complexes with Acetylpyridine Ligands as Antivascular Agents in vitro: Cytotoxic and Antiangiogenic Potential
Lana F., Sandra A., Ana K., Radmila J., Biljana D., Siniša R.
Synthesis of Diflunisal Thiazolidinones as Anticancer Agents
Şenkardeş S., Özakpınar Ö., Özsavcı D., Şener A., Çevik Ö., Küçükgüzel Ş.
In Vivo Anticancer Activity, Toxicology and Histopathological Studies of the Thiolate Gold(I) Complex [Au(Spyrimidine)(PTA-CH2Ph)]Br
Garcia-Moreno E., Gascon S., Garcia de Jalon J., Romanos E., Rodriguez-Yoldi M., Cerrada E., Laguna M.
Combined Anticancer Therapies: An Overview of the Latest Applications
Piccolo M., Menale C., Crispi S.
Promotion of Metastasis-associated Gene Expression in Survived PANC-1 Cells Following Trichostatin A Treatment
Chen Z., Yang Y., Liu B., Wang B., Sun M., Zhang L., Chen B., You H., Zhou M.
Caspases and ROS - Dependent Mechanism of Action Mediated by Combination of WP 631 and Epothilone B
Rogalska A., Bukowska B., Marczak A.
Role of Caspases, Bax and Bcl-2 in Chrysin-Induced Apoptosis in the A549 Human Lung Adenocarcinoma Epithelial Cells
Samarghandian S., Nezhad M., Mohammadi G.
Apoptosis Induction by Erucylphosphohomocholine via the 18 kDa Mitochondrial Translocator Protein: Implications for Cancer Treatment
Veenman L., Gavish M., Kugler W.
Pro-Oxidative Action of Polyphenols as Action Mechanism for their Pro-Apoptotic Activity
Lecci R., Logrieco A., Leone A.
BIBR 1532 Increases Arsenic Trioxide-mediated Apoptosis in Acute Promyelocytic Leukemia Cells: Therapeutic Potential for APL
Kazerani M., Hezave K., Hassani S., Rostami M., Alimoghaddam K., Ghavamzadeh A., Bashash D., H.Ghaffari S., Zaker F.
A Small-molecule Inhibitor, 5'-O-Tritylthymidine, Targets FAK and Mdm-2 Interaction, and Blocks Breast and Colon Tumorigenesis in vivo
M. Golubovskaya V., L. Palma N., Zheng M., Ho B., Magis A., Ostrov D., G. Cance W.
Differential Effects of Polyphenols on Proliferation and Apoptosis in Human Myeloid and Lymphoid Leukemia Cell Lines
Mahbub A., Maitre C., Haywood-Small S., McDougall G., Cross N., Jordan-Mahy N.
The Nuclear Orphan Receptors NR4A as Therapeutic Target in Cancer Therapy
J. A. Deutsch A., Angerer H., E. Fuchs T., Neumeister P.
The Role of Cdc25A in the Regulation of Cell Proliferation and Apoptosis
Shen T., Huang S.
Genistein and its Synthetic Analogs as Anticancer Agents
Li Q., Li C., Li Z., Zhu H.
S1P Regulation of Macrophage Functions in the Context of Cancer
Weigert A., Weichand B., Brune B.
Gold Nanostructures as Photothermal Therapy Agent for Cancer
Choi J., Yang J., Jang E., Suh J., Huh Y., Lee K., Haam S.
Irisquinone's Anti-cancer Potential: Targeting TrxR to Trigger ROS-mediated Apoptosis and Pyroptosis
Zhang Q., Wang X., Tana G., Liang G., Ma Y., Bu R., Ga L.
Effects of Citrus-derived Diosmetin on Melanoma: Induction of Apoptosis and Autophagy Mediated by PI3K/Akt/mTOR Pathway Inhibition
Li j., Xu M., Wu N., Wu F., Chen J., Xu X., Tan F., Liu Y.
Arctigenin Suppresses the Proliferation and Metastasis, and Induces Apoptosis and Cycle Arrest of Osteosarcoma Cells by inhibiting HMOX1 Expression
Xu G., He Z., Liu Y.
Novel Synthetic Indazoles Abrogate Angiogenesis in Erlich Ascites Tumor Bearing Mice
Ashwini N., Balaji K., Sadashivaiah B., Swaroop T., Jayarama S., Mantelingu K., Rangappa K.
ALK and ERBB2 Protein Inhibition is Involved in the Prevention of Lung Cancer Development by Vincamine
Verma A., Yadav P., Rajput S., Verma S., Arora S., Kumar R., Bhatti J., Khurana A., Navik U.
Gambogic Acid Lysinate-induced Cervical Cancer SiHa Cells Apoptosis in vitro and in vivo
Sun J., Liu Y., Guo J., Zhang X., Lin Y., Niu J.
Focal Adhesion Kinase Regulates Expression of Thioredoxin-interacting Protein (TXNIP) in Cancer Cells
Ho B., Huang G., Golubovskaya V.
Karanjin, A Promising Bioactive Compound Possessing Anti-cancer Activity against Experimental Model of Non-small Cell Lung Cancer Cells
Kumar G., Pandey D.M., Ghosh M., Dall'Acqua S., Gupta R., Tiwari N., Mohd Siddique U., Vishwakrama L., Guleri S.K., Lal U., Dubey S.
An Outlook of the Structure Activity Relationship (SAR) of Naphthalimide Derivatives as Anticancer Agents
Bhat A.
Apoptosis-inducing Metabolite from Marine Mangrove Actinobacteria VITGAP173
Gomathi A., Alagumuthu M., Sai P., Madhyastha H., Jayaraj R., Muthukailannan G.
Tabersonine Induces the Apoptosis of Human Hepatocellular Carcinoma In vitro and In vivo
Li X., Li X., Chen L., Deng Y., Zheng Z., Ming Y.
Aryl Maleimides as Apoptosis Inducers on L5178-Y Murine Leukemia Cells (in silico, in vitro and ex vivo Study)
Andrade-Jorge E., Godínez-Victoria M., Sánchez-Torres L., Fabila-Castillo L., Trujillo-Ferrara J.
The Alkylating-HDAC Inhibition Fusion Principle: Taking Chemotherapy to the Next Level with the First in Class Molecule EDO-S101
Mehrling T., Chen Y.
Apigenin and Breast Cancers: From Chemistry to Medicine
Nabavi S., Habtemariam S., Daglia M., Nabavi S.
Synthesis and Anticancer Activity Evaluation of Some Benzothiazole-Piperazine Derivatives
Gurdal E., Buclulgan E., Durmaz I., Cetin-Atalay R., Yarim M.
Mitogen-activated Protein Kinase Kinase 6-fusion Protein (MAP2K6-FP) Potentiates the Anti-tumor effects of Paclitaxel in Ovarian Cancer
Yuan J., Kang J., Liao H., Wang X., Nie M., Shuai R., Deng C.
Dinuclear Berenil-Platinum (II) Complexes as Modulators of Apoptosis in Human MCF-7 and MDA-MB231 Breast Cancer Cells
Agnieszka G., Ewa A., Anna B., Krzysztof B., Monika C., Elzbieta S.
The Indolylcoumarin COUFIN Exhibits Potent Activity Against Renal Carcinoma Cells without Affecting Hematopoietic System
Champelovier P., Barbier P., Daras E., Douillard S., Toussaint B., Persoon V., Curri V., Peyrot V., Combes S.
Lipid Rafts, Endoplasmic Reticulum and Mitochondria in the Antitumor Action of the Alkylphospholipid Analog Edelfosine
Gajate C., Mollinedo F.
White Poplar (Populus alba L.) Suspension Cultures as a Model System to Study Apoptosis Induced by Alfalfa Saponins
Balestrazzi A., Carbonera D., Avato P., Tava A.
Suppression of Oncoprotein Her-2 and DNA Damage after Treatment with Flavan-3- ol Vitis labrusca Extract
Scola G., Fernandes Correia Laurino C., Menin E., Salvador M.
Histone Deacetylase Inhibitors as Potential Therapeutic Agents for the Treatment of Malignant Mesothelioma
Katafygiotis P., Giaginis C., Patsouris E., Theocharis S.
Synthesis and Biological Evaluation of Diaryl Ether Linked DC-81 Conjugates as Potential Antitumor Agents
Ramaiah M., Murty J., Sultana F., Bharathi E., Ramakrishna G., Sarma P., Lavanya A., Pushpavalli S., Bhadra M., Kamal A., Viswanath A.
Gambogic Acid is a Novel Anti-cancer Agent that Inhibits Cell Proliferation, Angiogenesis and Metastasis
Wang X., Chen W.
Current and Emerging Strategies in Bladder Cancer
Carradori S., Cristini C., Secci D., Gulia C., Gentile V., Battista Di Pierro G.
Chemotherapeutic Targeting of Cell Death Pathways
Mansilla S., Llovera L., Portugal J.
Inhibition of Hyaluronan Synthase-3 Decreases Subcutaneous Colon Cancer Growth by Increasing Apoptosis
P. Teng B., D. Heffler M., C. Lai E., Zhao Y., M. LeVea C., M. Golubovskaya V., M. BullardDunn K.
FK506 Binding Proteins as Targets in Anticancer Therapy
Romano S., Di Pace A., Sorrentino A., Bisogni R., Sivero L., Fiammetta Romano M.
Discovery of a Novel Co-crystal of Chrysin and Oroxylin A with Anticancer Properties from Leaves of Oroxylum indicum
Singh S., Singh A., Singh A., Devi A., Korimayum M., Singh L.
Cyclic Lipopeptides as Selective Anticancer Agents: In vitro Efficacy on B16F10 Mouse Melanoma Cells
Hmedat A., Morejon M., Rivera D., Pantelic N., Wessjohann L., Kaluderovic G.
Cytotoxic and Apoptotic Impacts of Ceranib-2 on RAW 264.7 Macrophage Cells
Alanyalı f., Algı O.
Shikonin Causes Non-apoptotic Cell Death in B16F10 Melanoma
Ahmad H., Crotts M., Jacobs J., Baer R., Cox J.
Some Wild Mushrooms with High Antioxidant Capacity Exhibit Potent Anticancer Activity on Cancer Cells using the Apoptotic and Antimigration Cell Death Mechanisms
Şebin M., Yılmaz N., Aydın A.
Chloroform Fraction of Drymaria cordata Linn (CFDC) Suppresses Estradiol Benzoate- Induced Endometrial Hyperplasia
Olowofolahan A., Akinjiola O., Olanlokun J., Oyebode O., Aina O., Olorunsogo O.
Cordyceps militaris: A Comprehensive Study on Laboratory Cultivation and Anticancer Potential in Dalton's Ascites Lymphoma Tumor Model
Dutta D., Singh N., Aggarwal R., Verma A.
Bunium persicum Seeds Extract in Combination with Vincristine Mediates Apoptosis in MCF-7 Cells through Regulation of Involved Genes and Proteins Expression
Samandari-Bahraseman M.R., Ismaili A., Esmaeili-Mahani S., Ebrahimie E., Loit E.
A Novel Combinatorial Regimen Using Sorafenib and Uttroside B, A US FDA-designated ‘Orphan Drug’, for the Treatment of Hepatocellular Carcinoma
Keerthana C., Aiswarya S., Rayginia T., Vijayan Y., James S., Shifana S., Sundaram S., Induja D., Lankalapalli R., Harikumar K., Anto R.
A Green Synthesis of Au-Ag Alloy Nanoparticles using Polydopamine Chemistry: Evaluation of their Anticancer Potency Towards Both MCF-7 Cells and their Cancer Stem Cells Subgroup
Zhan H., Ding S., Shen R., Lv Y., Tian X., Liu G., Li C., Wang J.
In Vivo Inhibition of Proteasome Activity and Tumour Growth by Murraya koenigii Leaf Extract in Breast Cancer Xenografts and by Its Active Flavonoids in Breast Cancer Cells
Noolu B., Gogulothu R., Bhat M., Qadri S., Reddy V., Reddy G., Ismail A.
Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
Yurttas L., Demirayak S., Ciftci G.
A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents
Patil P., Satam V., Lee M.
Dual Induction of Mitochondrial Apoptosis and Senescence in Chronic Myelogenous Leukemia by Myrtucommulone A
Grandjenette C., Schnekenburger M., Morceau F., Mack F., Wiechmann K., Werz O., Dicato M., Diederich M.
A Novel Quinoline Based Second-generation mTOR Inhibitor that Induces Apoptosis and Disrupts PI3K-Akt-mTOR Signaling in Human Leukemia HL-60 Cells
Kumar S., Guru S., Venkateswarlu V., Malik F., Vishwakarma R., Sawant S., Bhushan S.
Differential Role of Apoptosis and Autophagy Associated with Anticancer Effect of Lupulone (Hop β-Acid) Derivatives on Prostate Cancer Cells
Mouratidis P., Colston K., Charolidi N., Pirianov G.
The Effect of Lycopene on the PI3K/Akt Signalling Pathway in Prostate Cancer
Chen J., O'Donoghue A., Deng Y., Zhang B., Kent F., O'Hare T.
Anticancer Agent Ukrain and Bortezomib Combination is Synergistic in 4T1 Breast Cancer Cells
Savran B., Yerlikaya A., Erdoğan E., Genç O.
Differential Effects of Antofine N-Oxide on Solid Tumor and Leukemia Cells
Bour T., Yang X., Li W., Bernardin F., Kaoma T., Muller A., Vallar L., Steinmetz A.
From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment
Babula P., Masarik M., Adam V., Provaznik I., Kizek R.
Myricetin Induces Apoptosis in HepG2 Cells Through Akt/p70S6K/Bad Signaling and Mitochondrial Apoptotic Pathway
Zhang X., Chen S., Tang L., Shen Y., Luo L., Xu C., Liu Q., Li D.
Pro-apoptotic Activity of BH3-only Proteins and BH3 Mimetics: from Theory to Potential Cancer Therapy
L. Hartman M., Czyz M.
Genistein Potentiates the Anti-cancer Effects of Gemcitabine in Human Osteosarcoma via the Downregulation of Akt and Nuclear Factor-κB Pathway
Liang C., Li H., Shen C., Lai J., Shi Z., Liu B., Tao H.
Potential Anticancer Properties of Bisphosphonates: Insights From Preclinical Studies
Clezardin P.
Targeting Cell Death and Survival Receptors in Hepatocellular Carcinoma
Muntane J.
Pomegranate Extract, A Prooxidant with Antiproliferative and Proapoptotic Activities Preferentially Towards Carcinoma Cells
H. Weisburg J., G. Schuck A., S. Silverman M., G. Ovits-Levy C., J. Solodokin L., L. Zuckerbraun H., Babich H.
Urea and Thiourea Derivatives of Salinomycin as Agents Targeting Malignant Colon Cancer Cells
Antoszczak M., Mielczarek-Puta M., Struga M., Huczynski A.
Origanum syriacum Induces Apoptosis in Lung Cancer Cells by Altering the Ratio of Bax/Bcl2
Yumrutas O., Yumrutas P., Pehlivan M., Korkmaz M., Kahraman D.
A Combination of EGFR Inhibitors and AE-PDT Could Synergistically Suppress Breast Cancer Progression
Niu Y., Guo X., Han W., Han X., Li K., Tian S., Zhu Y., Bai D., Chen Q.
Synthesis of S-2-phenylchromane Derivatives and Evaluation of the Antiproliferative Properties as Apoptosis Inducers in Cancer Cell Lines
Zhang Y., Ma J., Pei Y., Xie Z., Fu D., Li J.
Germacrone, A Novel and Safe Anticancer Agent from Genus Curcuma: A Review of its Mechanism
Lou G., Huang Y., Wang Y., Chen S., Liu C., Li Y., Feng J.
Erianin as a Promising Novel Agent in the Treatment of Neuroblastoma: The Anticancer Effects and Underlying Molecular Mechanisms
Kocoglu S., Seçme M., Sunay F.
Design and Synthesis of Aspirin-chalcone Mimic Conjugates as Potential Anticancer Agents
Mohamed-Ezzat R., Srour A.
An Active Compound from the Pyrazine Family Induces Apoptosis by Targeting the Bax/Bcl2 and Survivin Expression in Chronic Myeloid Leukemia K562 Cells
Rostampour S., Eslami F., Babaei E., Mostafavi H., Mahdavi M.
Silibinin Induces Both Apoptosis and Necroptosis with Potential Anti-tumor Efficacy in Lung Cancer
Zhang G., Wang L., Zhao L., Yang F., Lu C., Yan J., Zhang S., Wang H., Li Y.
Ginsenoside Rb1 Inhibits the Proliferation of Lung Cancer Cells by Inducing the Mitochondrial-mediated Apoptosis Pathway
Feng L., Liu X., Sun K., Sun Y., Wu W., Chen C., Jin X., Wan X.
Selective Toxicity of Apigenin on Cancerous Hepatocytes by Directly Targeting their Mitochondria
Seydi E., Rasekh H., Salimi A., Mohsenifar Z., Pourahmad J.
Generation of Redox Imbalance Mediates the Cytotoxic Effect of Malabaricone-A in a Multidrug Resistant Cell Line
Manna A., Bauri A., Chattopadhyay S., Chatterjee M.
Recent Trends of Chalcones Potentialities as Antiproliferative and Antiresistance Agents
Winter E., Locatelli C., Pietro A., Creczynski-Pasa T.
Using Cytochalasins to Improve Current Chemotherapeutic Approaches
Trendowski M.
Synthesis and Cytotoxic Properties of Halogen and Aryl-/Heteroarylpiperazinyl Derivatives of Benzofurans
Krawiecka M., Kuran B., Kossakowski J., Cieslak M., Kazmierczak- Baranska J., Krolewska K., Nawrot B.
A Steroidal Na+/K+ ATPase Inhibitor Triggers Pro-apoptotic Signaling and Induces Apoptosis in Prostate and Lung Tumor Cells
Honisch S., Alkahtani S., Kounenidakis M., Liu G., Alarifi S., Al-Yahya H., Dimas K., AlKahtane A., Prousis K., Al-Dahmash B., Calogeropoulou T., Alevizopoulos K., Lang F., Stournaras C.
Garlic-Derived Allyl Sulfides in Cancer Therapy
Cao H., Zhu K., Fan J., Qiao L.
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